Some research suggests that men who practice resistance training or bodybuilding may need higher doses of the amino acid to increase hormone levels, but there isn’t enough evidence to make this recommendation. In: Feldman M, Friedman LS, Brandt LJ, eds. Health Encyclopedia. We have a strict editorial process. Become an Examine Personalized member to access the latest nutrition research on over 400 supplements across more than 600 different health goals, outcomes, conditions, and more. Further research is needed on D-AA, as most studies attempt to assess D-AA’s role in the body under normal conditions, and not in the frame of supplementation. hough no scientific answers may support something similar, conclusions drawn up to date show that D-Aspartic Acid helps increase muscle mass and enhance endurance. Guyton and Hall Textbook of Medical Physiology. ScienceDirect ® is a registered trademark of Elsevier B.V. ScienceDirect ® is a registered trademark of Elsevier B.V. URL:, URL:, URL:, URL:, URL:, URL:, URL:, URL:, URL:, URL:, Reference Module in Biomedical Sciences, 2017, MODELS | Models of Generalized Seizures in Freely Moving Animals, Topography of chemically identified neurons in the central nervous system: progress in 1981–1983, Neurologic Aspects of Systemic Disease Part III, Dalmau et al., 2008; Florance et al., 2009, Modulation of 5-hydroxytryptamine and Noradrenaline Release in the Brain and Retina via Presynaptic Heteroreceptors: Some New Aspects, Presynaptic Receptors and Neuronal Transporters, Handbook of Proteolytic Enzymes (Third Edition), Goldstone et al., 2011; Powell, Holland, Hollis, & Perrino, 2011, Baldauf et al., 2012; Gelais et al., 2012; Kim, Nguyen, Daddacha, & Hollenbaugh, 2012; Laguette et al., 2011; Pauls et al., 2014, Behrendt et al., 2013; Rehwinkel et al., 2013, Hrecka et al., 2011; Laguette et al., 2011; Simon, Bloch, & Landau, 2015, Hollenbaugh et al., 2013; Kim, White, Brandariz-Nunez, Diaz-Griffero, & Weitzman, 2013. Many amino acid supplements are not regulated, and the doses reported on supplements may not be accurate. Plus 4 Substitutes, Detox Your Liver: Try My 6-Step Liver Cleanse, Epsom Salt — The Magnesium-Rich, Detoxifying Pain Reliever, Apple Cider Vinegar Benefits and Uses (30!). Aspartic acid and oxaloacetate, a compound that is known to boost brain health, are interconvertible and can transfer from one amino group to another. The side effects, observed in some cases, are of mild intensity and duration, however, if we are talking about the use of the D-Aspartic Acid supplement and not a supplement that includes this substance among its ingredients. There is no evidence to suggest that DAA will make you gain weight. D-AA can be used as a testosterone booster for infertile men, and by athletes as a temporary booster. NMDAr-Abs target the N-terminal extracellular domain of the NR1 subunit of the glutamate receptor NMDA and hamper the glutamatergic pathway by internalizing this receptor (Dalmau et al., 2007, 2008).